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reported that paricalcitol modulates the Angiopoietin-2/VEGF/VEGFR2 axis, attenuates TGF- related signaling, and preserves renal tissue architecture in an adriamycin nephropathy model ( In summary, vitamin D exerts renoprotective effects on renal fibrosis by suppressing profibrotic signaling, modulating multiple molecular pathways, and stabilizing the renal microenvironment

As an important structural component of green plants [44, 45] and some microorganisms [46], it is the most abundant biomaterial on earth

Fibrosis is measured histologically using the METAVIR staging system that ranges from 0 (no fibrosis) and increases to stage 4 (which represents hepatic cirrhosis)