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(New York, NY: Garland Science), 147151

Activation of the IP receptor results in the conversion of ATP to cyclic AMP (cAMP) which increases protein kinase A (PKA) activity, leading to downstream effects including vasodilation

The active center consists of a heme with a tyrosine ligand on the proximal side and a conserved histidine and an aspartate on the distal side

125(1): 1439 Grasemann H, Stehling F, Brunar H, et al

First, ACEs may drive long-standing sensitization of immune pathways, leading to a primed state [1]