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Despite recent advancements in the analysis of DNA methylation status and the promising findings of aberrant DNA methylation as a cancer biomarker, its clinical application remains limited due to several issues, including costs compared to current methods, as well as technical challenges related to sensitivity, reproducibility, quantification, and standardization [112]

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intramuscular route: count injections given Visit 3 (week 26) Anamnesis: record lifestyle habits and use of alcohol Symptoms: if pathological at the first visit, record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: if pathological at the first visit examine for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Request analyses to be performed one week before next visit: haemogram and serum vitamin B12 Questionnaire: EuroQoL-5D Assessment of adverse effects Therapeutic plan: patient in oral arm provision of medication