interaction of chloroacetamide electrophiles with cellular glutathion

interaction of chloroacetamide electrophiles with cellular glutathion Covalent inhibitors bacterial peptidoglycan biosynthesis enzyme MurA warhead Glutathione Dynamics in Subcellular Compartments

Name: interaction of chloroacetamide electrophiles with cellular glutathion Covalent inhibitors bacterial peptidoglycan biosynthesis enzyme MurA warhead Glutathione Dynamics in Subcellular Compartments
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Glutathione Dynamics in Subcellular Compartments and Implications for Drug Development PMC Targeting a Therapy Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors bioRxiv The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology Delineating cysteine reactive compound modulation of cellular proteostasis processes Nature Chemical Biology

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On day 4 or 6, macrophages were polarized with or without 100 ng ml 1 lipopolysaccharide (LPS) (Sigma) and 2050 ng ml 1 IFN (PeproTech) for 12 days

PMID: 11124012

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While these drugs can temporarily alleviate or stabilize symptoms, they are unable to stop the long-term progression of the disease and are associated with various side effects