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The toxicity of free heme is implicated in the pathology of the various etiologies of hemolytic disorders (hemolytic anemias, hemorrhagic strokes and traumas, malaria, sepsis, ischemia reperfusion injury and others [217])

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In the same vein, Prima et al

1 to 2 skin whitening injections can be injected in a week, so the complete treatment may take up to 3 months