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Rare, but serious, adverse events associated with the intravascular injection of soft-tissue fillers in the face have been reported and include temporary or permanent vision impairment, blindness, cerebral ischemia or cerebral hemorrhage leading to stroke, skin necrosis, and damage to underlying facial structures

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Moderate to Severe Deficiency: For moderate to severe deficiencies, the dosage may increase to 1,000 mcg several times a week initially, followed by a maintenance dose