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Molecular Profile Peptide: AOD-9604 Type: GH fragment (176191) analogue Sequence Length: 15 amino acids Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Gly-Phe-Tyr-Ser-OH Molecular Weight: ~ 1,813 Da Form: Lyophilized powder Purity: 98% (HPLC tested) Storage & Stability Store lyophilized peptide at 20C Protect from heat, moisture, and light Reconstituted solutions should be used promptly or stored per laboratory protocol Avoid repeated freeze-thaw cycles What the Research Shows About AOD-9604 & Cartilage 1

For more information FOXRED1 OMIM entry: NDUFA13 OMIM entry: NDUFB6 OMIM entry: Data availability The datasets produced in this study are available in the following databases: Raw RNAseq data and processed log 2 expression counts: ArrayExpress, European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI) ( under accession no

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In physiological settings wherein the GSH/GSSG redox couple is highly reduced, mammalian GLRX1 (hereafter referred to as GLRX) acts predominantly as a deglutathionylase 5

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For comparison, and as a control to assess the specificity of BDNF among other known neuronal activity-regulated paracrine factors 1,2,3 , soluble NLGN3 was similarly tested and exerted no acute effect on glutamatergic current amplitude in glioma cells (Extended Data Fig