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Vitamin D through the specific receptor (vitamin D receptor, VDR) affects the function of the central nervous system (neurons, microglia, and astrocytes), the cardiovascular system (vascular smooth muscle cells, pericytes, endothelial cells, and cardiomyocytes), tissue healing (fibroblasts), and epithelium [195]

Soluble A oligomers and protofibrils induce NLRP3 inflammasome activation in microglia

The acute augmentation of tumor cells consumes more nutrients than normal cells, so the metabolism of tumor cells requires a high consumption of oxygen and glucose [51]

For many other risk factors besides HBV itself, patients with HBsAg loss still need regular monitoring

Furthermore, when apoptosis and necroptosis fail to occur, caspase-8 can be involved in the activation of caspase-1 and inflammasome to trigger pyroptosis, a strongly proinflammatory cell death modality associated with the release of IL-1 and IL-18 [145, 146]

2018, DOI:10.3389/fped.2018.00313 [3]Zhou, Y, and N C Danbolt