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Takayama Y, Wakabayashi T, Kushige H, Saito Y, Shibuya Y, Shibata S, et al

The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM 5-TR) describes OUD as a pattern of opioid use leading to problems or distress, where at least two of the following occurring within a 12-month period: Taking larger amounts or taking drugs over a longer period than intended

Cyanocobalamin (sometimes included in semaglutide formulations) is a synthetic form of vitamin B12, not found in nature, but widely used in supplements due to its stability and cost-effectiveness