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Conformational changes in PDI alter its compact conformation and expose the normally shielded hydrophobic regions, which regulates its chaperone activity (Wang et al., 2012, 2015)

This doesn't mean glutathione is ineffective it simply means the science is still evolving, and consumers should approach it with informed, realistic expectations

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Carcinogenesis 27:811819 Nguyen T, Huang HC, Pickett CB (2000) Transcriptional regulation of the antioxidant response element