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10.1016/j.parkreldis.2023.105799 15 BraakH.Del TrediciK.RbU.de VosR

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In a unilateral PD rat model, rats were subjected to either 1 or 4 weeks intermittent moderate treadmill exercise (Fernandes Ferreira et al., Another study using a rodent model showed that exposure to 6-hydroxydopamine (6-OHDA) led to a reduction of mitochondrial factors adenosine monophosphate (AMP)-activated protein kinase, PGC-1, and tyrosine hydroxylase (TH), and increased expression of silent information regulator T1, TFAM, and p53 (Rezaee et al., 2019)