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demonstrated that OS triggers DNA methyltransferase 1 (DNMT1)-dependent methylation of ALDH promoters, resulting in decreased ALDH expression and -alanine synthesis and reducing carnosine availability

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Other possible sources for MG formation include the auto-oxidation of surgars, as well as the metabolism of acetone and aminoacetone ( FIGURE 1 MG Detoxification in Plants via Glyoxalase and Other Metabolic Pathways Methylglyoxal detoxification involves the conversion of MG to less toxic molecules, thus limiting its detrimental effects

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Afterwards, the culture medium was removed and replaced by assay medium (DMEM culture medium supplemented with 2% fetal calf serum, 2 mM L-glutamine, 50 U/ml penicillin, and 50 g/ml streptomycin) containing the test peptides or not (control)