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The most frequently reported side effects are nausea, vomiting, diarrhea, and constipation, driven by the combined effect both drugs have on slowing gastric emptying

Reported side effects Mild local irritation or discomfort at the injection site Headache (typically mild and short-lived) Nausea or dizziness in some patients Sweating Mild fever more commonly reported in post-stroke use, generally manageable with standard antipyretics Contraindications Cerebrolysin is not recommended for individuals with: Active epilepsy or seizure disorders Severe renal (kidney) impairment Known hypersensitivity to any component of the formulation Note: A 2023 Cochrane review noted a potentially higher rate of spontaneous adverse events in some stroke trial subgroups

Hortells, L., Johansen, A

But when combined with semaglutide, that number nearly doubled

Preclinical animal studies have shown that MK-677 does not affect normal negative feedback mechanisms in the GH pathway such as somatostatin

1A via Associated Press