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In Magnaporthe oryzae , the serine/threonine kinase, Rim15 , regulates autophagy-glutaminolysis coupling by modulating NAD-GDH, with glutamate to -ketoglutarate conversion contributing to the reactivation of TOR signaling and the suppression of autophagy upon nutrient recovery [96]

[144] reported that DDP triggered more mitochondria to be engulfed by the lysosome, facilitated LC3-II migration on the surface of mitochondria, and upregulated mitophagy markers, such as p62, BECLIN 1, and ATG5, in HeLa cells compared with those in normal cells

Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brstle A, Molyneux SD, Mason JM, Li WY, Yamamoto K et al (2015) Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

doi: 10.1038/s41598-025-04798-4 49 RostagnoMADArrigoMMartnezJA

Melanocytes produce melanin from an amino acid called tyrosine, through a multi-step process, by using a key enzyme called tyrosinase