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reassembly (optionally in combination with other directed evolution methods described herein) is performed as described herein, using polynucleotides that encode any one or more of the various proteasome components, including, for example, LMP2, LMP7, MECL-1 and other individual proteasome components that are specifically involved in class I epitope presentation

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For example, 20%31% of patients with Long COVID met the criteria for fibromyalgia more than 6 months after their COVID-19 infection (Fernndez-de-Las-Peas et al., 2022

De Rosa, S

While these studies involve relatively small groups of participants, their scientific and operational complexity is considerable