glutathione persister cells cancer

glutathione persister cells cancer cells: Iron addiction and vulnerability to ferroptosis: Molecular Cell Frontiers | Characteristics and molecular

Name: glutathione persister cells cancer cells: Iron addiction and vulnerability to ferroptosis: Molecular Cell Frontiers | Characteristics and molecular
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Frontiers Characteristics and molecular mechanism of drug tolerant cells in cancer: a review Glutathione peroxidase 4dependent glutathione highconsumption drives acquired platinum chemoresistance in lung cancerderived brain metastasis Liu 2021 Clinical and Translational Medicine Wiley Online Library Cancer drug tolerant persister cells: from biological questions to clinical opportunities PMC Targeting of vulnerabilities of drug tolerant persisters identified through functional genetics delays tumor relapse ScienceDirect Involvement of glutathione peroxidases in the occurrence and development of breast cancers Journal of Translational Medicine Springer Nature Link Drug induced tolerant persisters in tumor: mechanism, vulnerability and perspective implication for clinical treatment Molecular Cancer Springer Nature Link

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There is insufficient clinical trial data to confirm their efficacy and safety in humans

Huang X, et al

Inflammatory microglial necroptosis occurs, shutting down proinflammatory signals, and is followed by the repopulation of the lesion with regulatory microglia, a process required for efficient remyelination (Lloyd et al., 2019)