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Overall, our study provides a clinically translatable strategy to overcome the current challenges in the treatment of lumbar disc herniation

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Exploratory p-values should be interpreted with caution as they were not adjusted for multiple testing

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Either inhibition of XBP1 activity or inhibition of the rate-limiting enzyme in cholesterol synthesis restores CD8+ T-cell function in the tumor microenvironment and improves their antitumor activity after adoptive transfer

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