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[Google Scholar] Jiang BG, Jia N, Jiang JF, Zheng YC, Chu YL, Jiang RR, Wang YW, Liu HB, Wei R, Zhang WH, et al

Funding sources were as follows: DTR: R01GM115424 (NIH)

Evidence on the benefits of systemic therapy is limited for several reasons: reliance on mostly small and predominantly female samples, short study durations, methodologic heterogeneity, and a lack of consensus on which outcome measures are clinically relevant