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Since most early-onset point mutations are in this region (E46K, H50Q, G51D, A53T/V/E), it was deemed likely to be an important aggregation modulator and therefore a focal point for peptide aggregation inhibitor design

But for the masters cyclist population, we also want to take into account things like tooth and gum health, which arent helped by gels and high-carb sports drinks. The other issue, he says, is that he sees athletes using these drugs struggling with postride recovery