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Furthermore, extensive research suggests that OS may impact cognitive function through various pathways, such as directly damaging parvalbumin-expressing interneurons (PVIs) (Schiavone et al., 2009), hindering oligodendrocyte precursor cell (OPC) proliferation and myelin formation in the prefrontal cortex (PFC) (Maas et al., 2021), disrupting the bloodbrain barrier (BBB) (Geng et al., 2023), and inducing mitochondrial dysfunction (Fizikova et al., 2023)

Clin Cancer Res 17(8):25382548 Bender S et al (2016) Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

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In this respect, underweight mothers with a BMI 30 kg/m 2 are at risk of macrosomia and gestational diabetes (252)

BCKAs can promote the production of ROS due to their ability to cause mitochondrial respiratory dysfunction, indicating that the BCKA-ROS axis may contribute to the development of heart diseases (64)

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