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5 Discussion and perspectives In recent years, in OA, a complex degenerative joint disease, increasing research indicates that ferroptosis not only exists in the pathological process but is also closely related to pathological features such as articular cartilage degeneration, synovial inflammation, and subchondral bone changes

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aureus -induced osteomyelitis, elevated HIF-1 levels have been observed both in infected cell models and in murine samples (Zhang et al., 2022a

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Funding This work was supported by Macau government Grants FDCT-022/2015/A1 and FDCT-092-2015-A3, the University of Macau Grants MYRG2016-0019-ICMS -QRCM and MYRG2017-00147-ICMS awarded to Jia-Hong Lu