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In addition to succination, whose signalling is beyond the scope of this review and has been reviewed before [56], in the next sections, we will discuss the different signalling cascades triggered by FH loss and fumarate accumulation

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Its intrinsic properties, including high cell permeability, the ability to easily cross both the bloodbrain and placenta barriers, and its role as an endogenous reservoir of free radical scavengers (with indirect extra activities), confer it beneficial uses as an adjuvant in the biomedical field

The brain has a high level of metabolic activity and therefore cerebral tissues require an immediate and constant supply of oxygen

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