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By assigning metabolites to the signals shown in the loading plot (Figs 4B and S5B) and quantifying the variation observed for each metabolite among the different classes, we found that overall, vB12 treatment induced significant metabolic changes in Tbx1 +/ mice only (Figs 4A, S5A, and S6, Table S1, Group 3)

Biologics and antibody-based platforms followed with $284 million from only 2 rounds, reflecting concentrated investment in engineering-based modalities