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2.2.3 Modulation of the immune response Proper management of neuroinflammation is crucial to safeguarding neurons from inflammatory damage and promoting natural healing processes

The importance of ROS on NF-B activation is further supported by studies demonstrating that activation of NF-B by nearly all stimuli can be blocked by antioxidants, such as L-cysteine, N-acetylcysteine (NAC), thiols, green tea polyphenols, and vitamin E [185, 186], although this might be not very specific because antioxidants have multiple targets [187]

Ye C, Lu Y, Yuan Z, Mi M, Qi L, Yuan Y, et al

AF enhances HMGB1 and CRT release, boosts DC activation, and improves ICB efficacy

Quantitative RT-polymerase chain reaction analysis According to the manufacturers instructions, total RNA was isolated from mouse dorsal skin using RNAiso Plus, and the extracted RNA was quantitatively analyzed by spectrophotometry