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Furthermore, the key ferroptosis regulatory inhibitor GPX4 of the antioxidant system and its upstream regulatory target GSH expression were suppressed, and the cytotoxicity of EMFF against granulosa cells could be attenuated by an iron chelator and ferroptosis inhibitor but not by the apoptosis, necrosis, and autophagy inhibitor

A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism

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Metformin not only induces vitamin B12 depletion in serum, but also progressively increases methylmalonic acid (MMA) level in blood serum

2AC) revealed significant lymphopenia of multiple CD8- derived subsets in PBMCs from hospitalized COVID(+) patients (Fig