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The most serious consequences are neurological

Advise females of reproductive potential to use effective contraception during treatment with pemetrexed and for 6 months after the last dose

Gastroprotection & Cytoprotection : Consistent with its origin, BPC-157 has repeatedly reduced gastric and intestinal lesion severity in preclinical models and supported mucosal closure.[3] Nitric-Oxide System Balancing : BPC-157 has normalised haemodynamics in settings of both nitric-oxide deficiency and excess, pointing to a homeostatic effect on vascular tone and tissue perfusion

For the chronic dosing studies, most studies are looking at doses of 4 g/day.[ref] (This used to be the maximum recommended acetaminophen dose per day, but that has now changed to 3g/day.) For reference, a single over-the-counter Extra Strength Tylenol is 500 mg, with the directions saying not to exceed 6 tablets in 24 hours (so 3g/day)

1997 Jul;10(7):153541.

Our findings point to neurodevelopmental risks associated with insufficient amounts of prenatal B 12 , particularly in association with high levels of FA intake, suggesting that the neurodevelopmental program is sensitive to an imbalance in the status of these interacting micronutrients