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4.2 Systemic mechanism-of-action Systemic interventions have traditionally faced significant challenges due to the nature of the BBB and the complex immune dynamics of the brain

Co-immunoprecipitation and Western blot analysis indicated that auranofin inhibits Nrf2 degradation by inducing the dissociation of the Nrf2-Keap1 complex, resulting in nuclear accumulation of Nrf2

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These metabolic disturbances activate several pathogenic pathways that contribute to neuronal dysfunction and death, ultimately manifesting as DPN