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This recent rapid increase in demand (Watanabe et al., 2023), spurred in part by celebrity endorsements touting the cosmetic benefits of these drugs (Klein, 2023), led to an FDA-designated supply shortage of liraglutide, semaglutide, and tirzepatide

534,535 Combination therapy, starting with a single agent and titrating to the maximum tolerated dose, may enhance efficacy when pain control is inadequate, with recent studies suggesting superior pain relief compared to monotherapy

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If combining with other medications or supplements, discuss potential interactions with your provider