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I think the, the consensus in the field now is to use it with the rest of your skincare routine not in place of it

In some instances, a deficiency in B12 may present symptoms similar to hemolytic anemia, including intramedullary hemolysis and elevated levels of lactate dehydrogenase (LDH), which raises concerns about serious conditions like thrombotic microangiopathy (TMA) [3,4]

Subcutaneous injection of BV has been demonstrated to offer anti-nociceptive effects in mouse models for both visceral and somatic pain

& McMahon, F

44-46 High blood glucose levels trigger the production of large amounts of advanced glycation end-products (AGEs), proteins and lipids damaged by spontaneous reactions with glucose

1 2 3 Assessment report: Comirnaty (PDF) (European public assessment report)