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Antioxidants help your body neutralize free radicals and reduce oxidative stress: a key factor that can interfere with melatonin production, disrupt deep sleep, and affect your nervous system

Paeonol, a natural product isolated from Paeonia suffruticosa , inhibits ferroptosis via the HOTAIR/UPF1/ACSL4 axis in both in vitro and in vivo ICH models, improving neurological outcomes (207)

Mutimer, C

It is noteworthy that the temporal lobe and inferior frontal lobe had increased cerebral glucose metabolism post-treatment since these regions are known to support the cognitive processes which were perceived to be improved in the patients receiving NAC on self-reporting measures

A gut microbiota-mediated mechanism is also likely to exist, however how exactly the gut microbiota and (poly)phenols interact and to which extent this relationship influences their health benefits is one of the key questions that need to be answered to truly elucidate and identify which individuals will benefit the most from (poly)phenol consumption

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