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Rosa DD, Dias MMS, Grzekowiak M, Reis SA, Conceio LL, Peluzio Mdo CG

Instead, it may be that chronic diseases cause low glutathione levels, which then can exacerbate the conditions due to an inability to counteract the increasing levels of oxidative stress

Glutathione and Immune Function Kim, K

p62 was found to bind to the NRF2-binding site on KEAP1, thereby competing with NRF2 for KEAP1 binding [84]

In particular, Eadesgroup in 2011 identified and validated for the first time in MDA-MB-231 and Hs578T breast cancer cells a miRNA, miR-200a, able to target the KEAP1 3-untranslated region (3-UTR), leading to KEAP1 mRNA degradation and, consequently, NRF2 stabilization and translocation to the nucleus [178]

By regulating both the production of serine and glycine, as well as the enzymes that utilize these amino acids, NRF2 may better influence their fate by funneling them into antioxidant response pathways