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Within the ER, newly synthesised proteins are oxidised by PDI, which in turn are again re-oxidised by ER oxidoreductase 1 (ERO1) in a reaction that generates H 2 O 2 72 , reviewed by 76

Ketogenic diet The ketogenic diet is a high-fat, moderate protein, and extremely low-carbohydrate dietary pattern that has shown potential in recent years in the treatment of NDs by inducing the body to produce ketone bodies (such as beta-hydroxybutyric acid) as an alternative energy source

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FIGURE 7 Endothelial cell aging is closely associated with the progression of various diseases, potentially exacerbating the senescence of surrounding cells and worsening pathological processes (Hwang et al., 2022)