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The researchers propose that DSIPs observed effects, particularly the selective increase in V3 and ADP/t without affecting VDNP, suggest that it does not stimulate the activity of respiratory chain enzymes or substrate transporters, as these would typically affect VDNP

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Assay: Glutathione in mice brain and liver tissue

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The initial reaction rates at different concentrations of compound were used to determine EC 50 values, which were calculated with a four-parameter logistical model of log dose against percentage activation and were obtained from at least three sets of experiments