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Most of the total body Se pool (which is ~520 mg in the European and US population) is stored in the muscle (3050%), bones (15%), blood (10%), liver (8%), kidneys (3%), and brain (3%) (45)

Duan M, Leng S, Mao P

Unfortunately, mitochondria also produce reactive oxygen species as a byproduct of energy generation

To exclude other mechanistic possibilities of combination therapy in suppressing tumor growth by altering the TME, other cellular components including inflammatory cells and fibroblasts were analyzed