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Cotton NP, White SA, Peake SJ, McSweeney S, Jackson JB (2001) The crystal structure of an asymmetric complex of the two nucleotide binding components of proton-translocating transhydrogenase

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This observation sparked interest in developing medications that could boost incretin activity, potentially treating both diabetes and obesity

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Trials showed significant increases in GH release and growth velocity at 6 months, with efficacy reported through 36 months