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These findings highlight the dose-dependent toxicity of NAC and emphasize the need for cautious dosing, particularly in healthy individuals (159)

doi: 10.1016/j.celrep.2020.01.011 42 OuyangYOuZZhongWYangJFuSOuyangNet al

Synthesis, in vitro and in vivo characterization of glycosyl derivatives of ibuprofen as novel prodrugs for brain drug delivery

Pain 16 , 141147 (2008)

The delta sleep-inducing peptide inhibits CRH at the hypothalamic level, reducing the signal that drives ACTH release and, downstream, cortisol secretion from the adrenal glands