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The protease/anti-protease hypothesis, in which emphysema is caused by an imbalance of destructive proteases and their inhibitors (see heading The protease/anti-protease imbalance), has been widely accepted as a component of the pathophysiology of COPD

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J Autoimmun (2013) 45:319

Thereafter, the recruitment of monocyte-derived cells to the subendothelium activates immune response

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