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USA 100 , 51075112 (2003)

The first one involves irreversible damage to the ETC, possibly through TTC5 upregulation, resulting in ATP loss, increased mitochondrial superoxide production and caspases 3/7 activation, and subsequent apoptosis

These effects may include better moods, more energy, less fatigue, and a general sense of wellbeing

It is handled under controlled conditions as part of experimental workflows relating to biochemical and structural analysis

One nuance worth knowing: increased polyamine flux was actually framed as part of the benefit in the original obesity work, because cycling polyamines through synthesis and breakdown burns energy