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1,4 Hyperglycemia, dyslipidemia, and insulin resistance activate various metabolic pathways, resulting in oxidative stress, mitochondrial dysfunction, inflammation, and microvascular damage, culminating in neuronal injury, Schwann cell damage, and myelin sheath degeneration

J., Hejtmancik, M

Plates were coated with 0.01% PLO overnight at 37 C, followed by a second coating in 5 g/ml laminin for approximately 4 h at RT

Nature 582 , 129133 (2020)

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As a result, direct oral GSH administration does not result in significant systemic elevation of GSH levels, curbing its utility in treating neurodegenerative diseases