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Carcinogenesis and reactive oxygen species signaling: interaction of the NADPH oxidase NOX1-5 and superoxide dismutase 1-3 signal transduction pathways

Fernndez A, Llacuna L, Fernandez-Checa JC, Colell A

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Notably, since obesity is characterized by adipose tissue hypoxia, HIF-1 expression and activity resulted increased in obese conditions, with a consequent release of pro-inflammatory signals (64-66)