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MMPs initiate large-scale collagen breakdown by cleaving a small moiety of extracellular collagen after it binds to cell surface receptors

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Studies have demonstrated that patients with Long COVID and ME/CFS exhibit impaired function of Transient Receptor Potential Melastatin 3 (TRPM3) ion channels on their NK cells

Ischemic strokes account for approximately 87% of all strokes in the United States and are characterized by a focal blockage within the cerebrovascular network that leads to a limited blood supply to the brain [1,4]

Similarly, HGF exerts potent protective effects by inhibiting oxidative stress, stimulating hepatocyte proliferation via ERK1/2 activation, upregulating glutathione and downregulating ICAM-1 expression, thereby suppressing neutrophil adhesion and migration (58)