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Modern clinical research has shown that saffron supplementation (typically 2050mg per day) can improve visual acuity, retinal function, and contrast sensitivity in adults with AMD.58 These effects are attributed to compounds called crocin and crocetin, which may enhance retinal blood flow and protect photoreceptor cells from oxidative stress

Other environmental exposures, which have been related to DNA methylation, such as exposure to tobacco smoke [13-17] and air pollution [18], are out of the focus of the present review, as tobacco smoke and air pollution are mixtures of different types of chemicals rather than individual groups of compounds

Keeping in mind health-promoting properties of nutraceuticals along with their great therapeutic potential and safety profile, there is a permanently growing demand on the application of mitochondria-relevant nutraceuticals

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While these findings highlight the potential of EMS as a complementary strategy, future research could explore its application in clinical populations with limited physical capacity, where traditional RT may be less feasible (Thapa et al., 2023)