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Briefly, administration of testosterone and synthetic androgens in cell cultures provided strong time-course evidence of androgen action on intracellular calcium (Ca 2+ ) homeostasis, as well as activation of protein kinases A/C (PKA/PKC), MAPK, phosphatidylinositol-3 kinase (PI3K), protein kinase B (Akt), and cAMP response element-binding protein (CREB) [117]

Carr, S

[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Karpati G., Carpenter S., Engel A.G., Watters G., Allen J., Rothman S., Klassen G., Mamer O.A

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Third, increased inflammatory cytokines (e.g., IL-1, IL-6, TNF-, and IFN-) disrupt BBB integrity and induce neuroinflammation