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Similarly, systemic TB-500 administration in rats, dogs, and primates was well tolerated up to 60 mg/kg intravenously, with no histopathological abnormalities reported

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Of the total number of fondaparinux sodium-treated patients in these orthopedic surgery studies, 1,111 (30.9%) were 65 years of age to 74 years of age, while 1,227 (34.2%) were 75 years of age and older

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[1] Because the ingredients are compounded rather than supplied as an FDA-approved fixed-dose product