glutathione synthesis in erythrocytes The Role of Metabolism Chronic Illness Development and Its Potential Use as a Novel Therapeutic Target Glutathione Metabolism - an overview

doi: 10.1038/s41581-020-0297-2 276

2021ZKZD015, 2021ZKZD018, and 2021ZKMS046)

doi: 10.3389/fphar.2026.1765974 Received 11 December 2025 Revised 22 February 2026 Accepted 27 February 2026 Published 09 April 2026 Volume 17 - 2026 Edited by Shaoqiu Chen, University of Hawaii at Mnoa, United States Reviewed by Jingyu Wang, Peking University, China William Reeves, University of Texas Long School of Medicine, United States Updates Copyright 2026 Chen, Zheng, Huang and Zhang

Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW (2000) Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

mtDNA levels do recover in patients after discontinuation of HAART (Ct et al., 2002), but due to generation of somatic mutations by antiretrovirals and ROS, it is likely that replenished mtDNA harbors mutations predisposing the recuperating mitochondria to continued dysfunction

Giugliano D, Scappaticcio L, Longo M, et al