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No published study has tested this split approach directly, but the pharmacological logic holds: maximize both local concentration and systemic delivery

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The majority of patients with ALN initially present with symmetrical polyneuropathy mainly in the lower distal extremities since primarily the initial manifestations occur in the most distal part of the axons [70]

Recently, GO has also been synthesized using the bottom-up method with strong oxidizers

For a quick reference sheet, see our encyclopedic guide to BPC-157