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If DNA synthesis and/or methylation (epigenetic events) are altered in utero, this could affect gene expression thus impacting fetal development and that could modulate the fetal susceptibility to various diseases

We also conducted an intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin tolerance test in 8-week-old male NAS mice and male C57BL/6 mice (control)

Segura et al., 2014

The random term ij represents the random error, which was assumed to be normally distributed, j represents the random effect for patient, and 0 represents the intercept