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Paracetamol poisoning Paracetamol poisoning , also known as acetaminophen poisoning , is caused by excessive use of the medication paracetamol (acetaminophen)

Marrack P, Kappler J

Under stimulation by lipopolysaccharide (LPS) and interferon- (IFN-), macrophages adopt the M1 phenotype ( 3 Macrophage metabolic states and tumor function Macrophage polarization is tightly governed by distinct metabolic programs that determine their effector functions within the tumor microenvironment ( 3.1 Oncogenic functions of tumor-associated macrophages Tumor-associated macrophages (TAMs) represent macrophages recruited and reprogrammed by the tumor microenvironment (TME), exhibiting distinct functional differences from conventional immune macrophages

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This initial insult leads to a wave of crypt cell apoptosis, resulting in a loss of intestinal regenerative capacity

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