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To limit these primary, deleterious consequences, hepatocytes develop a secondary adaptive response, triggered by ROS-responsive transcription factors, mainly the Nfr2/Keap1 system

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Khrunin et al., 2010), although Dhawan et al

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The authors suggested this was due to the hamstrings struggling to eccentrically control the concentric action of your quad as it straightens your leg during activities like running