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TB-500: Notch Signaling Angiogenesis & Differentiation Studies suggest TB-500 promotes angiogenesis likely through the Notch signaling pathway, which regulates cell fate decisions and vascular development[5]

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The cells were serum deprived for 24 h prior to the treatment to reduce the basal levels of phospho-Met

Interestingly, in human tumour cells exposed to genotoxic or metabolic stress, the level of UVRAG expression was upregulated at early time points (for example, 12 h) and restored to normal levels at later time points (for example, 36 h) by immunofluorescence and western blot analyses (Fig 1AC)